Antibacterial activity of seminalplasmin, a basic protein from bovine seminal plasma

K H SCHEIT, M ZIMMER, N SHYAMALA RAO, K S N PRASAD & P M BHARGAVA

Published in: Microbios, 1986, 45, 105-112.

Abstract:

Seminalplasmin,  a 6,000 dalton antimicrobial protein present in bovine seminal plasma, is shown to inhibit growth and/or RNA synthesis in several bacterial species. In only one strain out of twenty one belonging to fourteen species, did both RNA synthesis and growth appear to be resistant to seminalplasmin. The antibacterial activity of seminalplasmin, in the case of E. coli, was also studied as a function of its concentration and of time; the minimal concentration of the protein required for 100% bactericidal activity was only about twice that required for 100% bacteriostatic activity. The killing of E. coli cells proceeded in two phases, a slow phase and then a rapid one, and required several hours for completion. Several bacterial species tested secreted proteases into the medium that destroyed seminalplasmin.

PMID: 2423852

Keywords:
Animals
Anti-Bacterial Agents/pharmacology*
Bacillus subtilis/drug effects
Bacteria/drug effects*
Bacteria/enzymology
Bacteria/growth & development
Bacteria/metabolism
Cattle
Enterobacteriaceae/drug effects
Enterococcus faecalis/drug effects
Escherichia coli/drug effects
Escherichia coli/growth & development
Escherichia coli/metabolism
Kinetics
Male
Peptide Hydrolases/metabolism
Proteins/metabolism
Proteins/pharmacology
Pseudomonas aeruginosa/drug effects
RNA, Bacterial/biosynthesis
Semen
Seminal Vesicle Secretory Proteins
Staphylococcus aureus/drug effects

HOW TO CITE

Antibacterial activity of seminalplasmin, a basic protein from bovine seminal plasma. K H SCHEIT, M ZIMMER, N SHYAMALA RAO, K S N PRASAD & P M BHARGAVA. Microbios, 1986, 45, 105-112.

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