Inhibition of reverse trnascriptase by seminalplasmin

E S P REDDY1, M R DAS, E PREMKUMAR REDDY2 & P M BHARGAVA1

Published in: Biochemical Journal, 1983, 209, 183-188.

Abstract:

Seminalplasmin, an antibacterial protein present in bovine seminal plasma, is shown to be a potent inhibitor of reverse transcriptases (RNA-dependent DNA nucleotidyltransferases). Seminalplasmin inhibits RNA-directed, hybrid-directed, and DNA-directed DNA-polymerizing activities of purified reverse transcriptase from avian myeloblastosis virus and from crude viral lysates of several retroviruses by binding to the enzyme, at least in the case of avian myeloblastosis virus. Seminalplasmin does not inhibit significantly DNA synthesis either by Escherichia coli DNA polymerase I, or a mammalian alpha-DNA polymerase. The presence of seminalplasmin in the seminal fluid could provide protection to the male and/or the female reproductive tract against retroviruses.

PMID: 6189479

Keywords:

Avian myeloblastosis virus/enzymology, DNA/biosynthesis, Polynucleotides/metabolism, Proteins/pharmacology, RNA, Messenger/metabolism, Retroviridae/metabolism, Reverse Transcriptase Inhibitors, Seminal Vesicle Secretory Proteins, Transcription, Genetic/drug effects

HOW TO CITE

Inhibition of reverse trnascriptase by seminalplasmin. E S P REDDY, M R DAS, E PREMKUMAR REDDY & P M BHARGAVA. Biochemical Journal, 1983, 209, 183-188.

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