Liver cells in suspension synthesise but do not secrete the newly synthesized serum albumin

L F HUSSAIN & P M BHARGAVA

Regional Research Laboratory, Hyderabad-9, India

Published in: Archives of Biochemistry & Biophysics, 1974, 161, 1530-160.

Abstract:

Rat liver cells in suspension, prepared in high yields by a mechanical dispersion method, have been shown to incorporate labeled amino acids into serum albumin at a rate comparable to that obtained in slices from unperfused or citrate-perfused liver over a 2-hr period. However, while in the two types of slices, on an average, 89% of the newly synthesized albumin is secreted into the medium in 2 hr, in the cell suspensions only 9% is secreted; the block to secretion in the cell suspension is confined only to albumin synthesized after dispersion of the tissue, and does not extend equally either to albumin synthesized prior to dispersion of the tissue to a single cell suspension, or to other proteins synthesized in the cell suspensions.

HOW TO CITE

Liver cells in suspension synthesise but do not secrete the newly synthesized serum albumin. L F HUSSAIN & P M BHARGAVA. Archieves of Biochemistgry & Biophysics, 1974, 161, 1530-160.

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