A possible role of permeability controls in regulation of cell division

| March 22, 2015 | 0 Comments

P M BHARGAVA

Published in: In Biomembranes (Proceedings of an International Symposium, Ed. L Packer) (Academic Press, New York, 1974), pp.381-406.

Abstract:

Our interest in models of regulation of cell growth based on control of permeability derives from three basic considerations:

(a) All types of cells from higher organisms in which the phenomenon of malignancy is encountered are auxotrophic for certain nutrients (the “essential nutrients”).

(b) The cells need to take up the essential nutrients from the environment, both for cell maintenance and for growth. In other words, these nutrients must be transported from the environment into the cell, across the cell membrane, in resting as well as in dividing cells.

(c) Available data on the rates of turnover, for example of macromolecules, in resting cells, and on the rates of growth of dividing cells of higher organisms, indicate that the rate of uptake of essential nutrients in growing cells must be many-fold higher than that in resting cells.

HOW TO CITE

A possible role of permeability controls in regulation of cell division. P M BHARGAVA. In Biomembranes (Proceedings of an International Symposium, Ed. L Packer) (Academic Press, New York, 1974), pp.381-406.

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