Regulation of cell division and malignant transformation

P M BHARGAVA & S A CHANDANI

Centre for Cellular & Molecular Biology, Hyderabad, India.

Published in: Bioscience Reports, 1988, 8, 519-529.

Abstract:

The problem of regulation of cell division is essentially a problem of understanding regulation of transition from the resting state of a cell to the dividing state and vice versa. In malignancy the ability to revert back to a normal resting state is impaired. A model is presented which attempts to explain the control of the above transitions through control of uptake of essential nutrients by a transport-inhibitory protein. Experimental evidence in favour of the model is given.

PMID: 3242639

Keywords:
cell division; malignancy; transformation; nutrient uptake; resting state.

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Regulation of cell division and malignant transformation. P M BHARGAVA & S A CHANDANI. Bioscience Reports, 1988, 8, 519-529.

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