Social isolation following embryo transfer increases success rates in IVF and ICSI cycles

Kamini A Raoa , M.S. Srinivasb, Anu Kotturc, Partha P Majumderd, Pushpa M Bhargavae,*

a Medical Director, Bangalore Assisted Conception Centre Private Limited, Bengaluru, Karnataka, India
b Embryologist, Bangalore Assisted Conception Centre Private Limited, Bengaluru, Karnataka, India
c Consultant, Bangalore Assisted Conception Centre Private Limited, Bengaluru, Karnataka, India
d Director, National Institute of Biomedical Genomics, Kalyan, West Bengal, India
e,* Scientist, Anveshna, Andhra Pradesh, India

*Author for correspondence (Pushpa M Bhargava, Anveshna, 2-16-137/1 Road No. 3, Prashanthi Nagar, Uppal, Hyderabad-500039, Andhra Pradesh, India.

Phone: +91-40-27200982; +91-40-27200954
Fax: +91-4027200868
e-mail: bhargava.pm@gmail.com, pmb1928@yahoo.co.in

International Journal of Fertility and Foetal Medicine: 2012, 3(1), 8-14.

Abstract:

Background and objective:

Bruce et al had shown, during 1959 to 1968, that if, 24 hours after mating, a mouse belonging to a different inbred strain than the stud mouse was placed in the cage of the female mouse, partitioned in such a way that no physical contact of the nonstud male with the female was possible, pregnancy was blocked. We, therefore, decided to determine whether, by analogy with mice, isolation of women from all other men except the husband, for 3 days after embryo transfer following in vitro fertilization (IVF) or intracycloplasmic sperm injection (ICSI), increases the establishment of pregnancy.

Method:

We isolated randomly selected 729 women from all other men except the husband for 3 full days after embryo transfer following IVF/ICSI, and followed them to the end of pregnancy; 1005 randomly selected women who were treated similarly but not isolated served as the control group.

Results:

The establishment of clinical pregnancy as well as live births were more than 50% higher in the isolated group than in the control.

Conclusion:

The social isolation as mentioned above could substantially increase the success rates in IVF or ICSI. While the exact mechanism of this phenomenon is yet to be understood, one possible explanation may be, by analogy with mice, an olfactory block to implantation.

DOI: 10.5005/jp-journals-10016-1033

Keywords:
ICSI, IVF, Social isolation

HOW TO CITE

Social isolation following embryo transfer increases success rates in IVF and ICSI cycles.  Kamini A Rao, M.S. Srinivas, Anu Kottur, Partha P Majumder, Pushpa M Bhargava. International Journal of Fertility and Foetal Medicine: 2012, 3(1), 8-14.

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