Studies on the structure of the skin protein-bound compound following topical application of 1,2,5,6-dibenzanthracene-9,10-C14 , PART I: 2-phenylphenanthrene 3, 2-dicarfboxylic acid, a degradation product

P M BHARGAVA, H I HADLER & C HEIDELBERGER

Published in: Journal of the American Chemical Society, 1955, 77, 1877-1886.

Abstract:

Studies on the structure of the protein-bound compounds following the application of l, 2, 5, 6-dihenzanthrazene-9, 10-C14 to the skin of mice have been carried out by the tracer technique. The binding, which is correlated with carcinogenesis, survives pepsin hydrolysis and must be covalent in nature. Alkaline hydrolysis liberates carboxylic acids and amino acid bound metabolites. Carrier experiments have shown that 2-phenylphenanthrene-3, 2′-dicarboxytic acid is present in the hydrolysis mixture; oxidative hydrolysis increases the amount of this compound to 23% of the total bound radioactivity. Some implications of these findings have been discussed.

HOW TO CITE

Studies on the structure of the skin protein-bound compound following topical application of 1,2,5,6-dibenzanthracene-9,10-C14 , PART I: 2-phenylphenanthrene 3, 2-dicarfboxylic acid, a degradation product. P M BHARGAVA, H I HADLER & C HEIDELBERGER. Journal of the American Chemical Society, 1955, 77, 1877-1886.

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