Studies on the structure of the skin protein bound compounds following topical application of 1,2,5,6-dibenzanthracene-9-10-C14, PART II: nature of the 2-phenylphenanthrene-3’-dicarboxylic acid-protein bond

P M BHARGAVA & C HEIDELBERGER

Published in: Journal of the American Chemical Society, 1956, 78, 3671-3677.

Abstract:

We have previously shown that 2-phenylphenanthrene-3, 2′-dicarboxylic acid (PDA) is obtained on the alkaline hydrolysis of the protein-bound compounds following the application of 1,2,5,6-dibenzanthracene-9,10-Cl4 to the skin of mice. By hydrazine treatment of the proteins and by carrier experiments, it has now been demonstrated that 25% of the proteinbound radioactivity involves the binding of PDA to the protein, partly through the diamide and partly through a monoamide of the acid.

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Studies on the structure of the skin protein bound compounds following topical application of 1,2,5,6-dibenzanthracene-9-10-C14, PART II: nature of the 2-phenylphenanthrene-3’-dicarboxylic acid-protein bond. P M BHARGAVA & C HEIDELBERGER. Journal of the American Chemical Society, 1956, 78, 3671-3677.

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