Uptake in vitro of nucleic acid precursors and of nucleic acids by Zajdela ascitic hepatoma cells

P M BHARGAVA, D SZAFARZ, C A BORNECQUE & F ZAJDELA

Published in: Journal of Membrane Biology, 1975, 22, 341-356.

Abstract:

Zajdela ascitic hepatoma cells are shown to take up pyrimidine bases at much lower rates than obtained in slices from normal rat liver. The rates of uptake of adenine and uridine by the Zajdela cells are, however, as high as in the slices. Like the slices, again, the Zajdela cells take up E. coli RNA and DNA at very low rates but, unlike the slices, thses cells degrade rapidly the RNA taken up. The Zajdela cells resemble parenchymal cell suspensions derived from normal rat liver in regard to the uptake of pyrimidine bases and the ability to degrade heterologous RNA.

PMID: 169353

Keywords:
Adenine/metabolism, Biological Transport, Carcinoma, Hepatocellular, Cell Line, DNA/metabolism, DNA, Bacterial/metabolism, Liver/metabolism, Liver Neoplasms, Orotic Acid/metabolism, RNA/metabolism, RNA, Bacterial/metabolism, Ribonucleosides/metabolism, Uracil/metabolism, Uridine/metabolism

HOW TO CITE

Uptake in vitro of nucleic acid precursors and of nucleic acids by Zajdela ascitic hepatoma cells. P M BHARGAVA, D SZAFARZ, C A BORNECQUE & F ZAJDELA. Journal of Membrane Biology, 1975, 22, 341-356.

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